In his 1927 essay ‘On Being One’s Own Rabbit’, the British-Indian scientist and writer J.B.S. Haldane surveyed the history of an enduring but contentious approach to scientific discovery: self-experimentation. At the age of eight, Haldane tested poison gases on himself in his scientist father’s home laboratory. As an adult, among other self-experiments occasioning losses of consciousness from ‘blows on the head, from fever, anaesthetics, want of oxygen and other causes’, he once induced sufficiently high levels of oxygen saturation to suffer a violent seizure and the crushing of several vertebrae.
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